A versatile strategy to screen libraries and control geometry of multidentate ligands
نویسنده
چکیده
Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the optimal geometry in multivalent interactions. WINSSINGER, Nicolas. DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands. Artificial DNA, 2012, vol. 3, no. 3, p. 1-4 DOI : 10.4161/adna.21108
منابع مشابه
DNA display of PNA-tagged ligands A versatile strategy to screen libraries and control geometry of multidentate ligands
Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the optimal geometry in multivalent interactions. WINSSINGER, Nicolas. DNA display of PNA-tagged ligands...
متن کاملA General Synthetic Route to Defined, Biologically Active Multivalent Arrays
A new, general strategy for the synthesis of biologically active multivalent arrays displaying diverse functionality has been developed. This method exploits the ability of ring-opening metathesis polymerizations to produce polymers of defined lengths. By incorporating N-hydroxysuccinimide esters into the polymers, recognition epitopes bearing nucleophilic functional groups, in this case an R-m...
متن کاملMediator-template assembly of nanoparticles.
The ability to construct size- and shape-controllable architectures using nanoparticles as building blocks is essential for the exploration of nanoparticle-structured properties. This paper reports findings of an investigation of a mediator-template strategy for the size-controllable assembly of nanoparticles. This strategy explores multidentate thioether ligands as molecular mediators and tetr...
متن کاملTransition metal dinitrogen complexes supported by a versatile monoanionic [N2P2] ligand.
By adjusting to the steric and electronic requirements of differing metal centers, the new multidentate monoanionic ligand [N(2)P(2)] has demonstrated a unique ability to stabilize a range of transition metal-dinitrogen complexes in a variety of oxidation states and coordination geometries.
متن کاملNovel titanium complexes of a multidentate dicarbollide ligand. Synthesis and structural characterization of a constrained geometry complex.
The multidentate dicarbollide ligand nido-7,8-(NMe2CH2)2-7,8-C2B9H11 has been prepared, structurally characterized, and employed in the preparation of the novel mono- and trimetallic titanium complexes [eta5:eta1-(NMe2CH2)C2B9H9CH2NMe2]Ti(NMe2)2 and [eta5:eta1-[(NMe2CH2)C2B9H9CH2NMe2]Ti(NMe2)]2-mu3-O-Ti(NMe2)2.
متن کامل